The No. 4-ranked Duke Blue Devils (25-6, 10-2 ACC) are coming off a 63-51 win over No. 6 Connecticut on Monday.
Duke had won its last five games in the series.
The Blue Devils, who have lost their last four games, are currently holding the No. 5 seed in the NCAA Tournament.
The Blue Devils had won their last five regular season games against the Huskies, who are 8-4 overall and 8-5 in ACC play.
In the last meeting, Duke won by 19.5 points with 9:52 remaining in the second half, then held the Husky to 18.7 percent shooting and outrebounded them 46-24.
The Huskies have won eight straight against Duke and have won four of their last six meetings in Durham.
The Huskies are 7-0 in the ACC Tournament, including an 8-0 record in the past six seasons.
They have won nine straight against North Carolina.
The Duke-Conn Huskies series has a lot of similarities to the 2006-07 season between Duke and Duke and Syracuse.
After a dominant performance at home to win their first ACC regular season title, the Huskers fell to North Carolina in the national semifinals.
In 2010, the Blue Devils defeated the Husks, 54-41, in Durham, making it the first time since 1984-85 that the Blue Demons would defeat the Huskeyes in the Final Four.
This was the first game in which the Husker’s players scored more than 20 points and Duke’s players had 21 or more points in a game.
In the NCAA tournament, Duke has won nine of 10 games against Duke, including the last four in Durham and the ACC Championship.
The Red Devils have won three of their four overall meetings with Duke, while the Blue Jackets have won two of the four overall matchups with the Blue Devil.
The No. 3 seed Connecticut (16-8, 6-8) lost to No. 7 Duke on Monday in Durham to open the NCAA tourney.
Connecticut had lost six straight overall to the Huskins and were one game behind the Blue Demon squad.
The Tigers are 8.5 games behind the Huskens in the Atlantic Coast Conference standings.