How Sound Waves Could Help Regrow Bones

The researchers used sound waves to turn stem cells into bone cells, as part of tissue engineering that could one day help patients rebuild bones lost to cancer or degenerative diseases.

Innovative stem cell therapy from RMIT researchers offers a smart way forward to overcome some of the biggest challenges in the industry, thanks to the power of high-frequency sound waves.

Tissue engineering is a new field that aims to repair bones and muscles using the natural ability of the human body to itself.

A key challenge in bone regeneration is the need for large numbers of bone cells that will thrive and thrive after implantation in the target area.

To date, in the experimental processes of transformation of adult stem cells into bone cells used sophisticated and expensive equipment and struggled with mass production, making widespread clinical application unrealistic.

In addition, in several clinical trials that tried to repair bone, mostly stem cells extracted from the patient’s bone marrow were used – a very painful procedure.

In a new study published in the journal SmallThe RMIT research team has shown that stem cells treated with high-frequency sound waves are rapidly and efficiently transformed into bone cells.

Importantly, the treatment was effective for a variety of cell types, including fat stem cells, which are much less painful to extract from the patient.

Research Fellow Dr. Amy Helmy said the new approach was faster and simpler than other methods.

“Sound waves reduce the treatment time it usually takes for stem cells to start turning into bone cells by a few days,” said Helmy, a researcher at RMIT Vice Chancellor.

“This method also does not require any special drugs that cause bone, and it is very easy to apply to stem cells.

“Our research has shown that this new approach has great potential for use to treat stem cells before we either apply them to an implant or inject them directly into the body for tissue engineering.”

The high-frequency sound waves used in stem cell therapy were created on an inexpensive microchip developed by RMIT.

Leading researcher, Distinguished Professor Leslie Yeo and his team have been studying the interaction of sound waves at frequencies above 10 MHz with various materials for more than ten years.

The device developed by them for generation of sound waves can be used for exact manipulation of cages, liquids or materials.

“We can use sound waves to put the right amount of pressure in the right places on the stem cells to start the process of change,” he said.

“Our device is cheap and easy to use, so it can be easily expanded to handle a large number of cells at once – vital for efficient tissue engineering.”

The next stage of research is to study methods to increase the scale of the platform, work on the development of practical bioreactors for effective stem cell differentiation.

Help: Ambattu LA, Gelmi A, Yeo LY. Short-term high-frequency nanomechanostimulation of the megahertz order leads to early and sustained osteogenic differentiation in mesenchymal stem cells. Small. 2022: 2106823. DOI: 10.1002 / smll.202106823

This article is republished from the following materials. Note: The material may have been edited in length and content. For more information, please contact the cited source.

Leave a Comment