£3 million funding for research into technology that could cure heart failure

The British Heart Foundation is announcing £ 3 million to study regenerative technologies that could cure heart failure.

This year, eight cutting-edge projects on heart failure will receive millions of pounds from the British Cardiology Foundation (BHF), and the money was raised, quite appropriately, at the London Marathon.

Longevity.Technology: Heart disease is the biggest killer in the world, with cardiovascular disease (CVD) taking about 17.9 million lives each year [1]. Due to the shortage of organs for transplantation, the focus will be on restorative medicine – to make the heart recover – and the BHF plans to fund eight projects, all aimed at finding ways to treat heart failure. Given that the picture contains a thousand words, BHF has taken a smart step by demonstrating this regenerative study through a stunning set of images demonstrating the Foundation’s desire not only to alleviate heart disease symptoms or prolong patients ’lives, but also to treat heart disease by regenerating, repairing or repairing cells. and fabrics.

“Heart failure is a debilitating disease that is affecting the lives of almost 1 million people in the UK,” said Professor Metin Avkiran, BHF’s Deputy Medical Director. “BHF-funded research has bright treatments to give people with heart failure a longer and healthier life, but there is no cure. Regenerative medicine gives such hope.

“The money raised at the London TCS 2022 marathon will allow these researchers to push the boundaries of medicine by finding ways to teach the heart to recover. Unlocking these secrets can help heal hearts and change outcomes for people living with devastating heart failure. ”

Growth of heart muscle from stem cells

© Professor Stefan Hoppler, University of Aberdeen

The red threads in the image above show a protein called Troponin T, which plays a crucial role in contracting and relaxing the heart muscle. Professor Stefan Hoppler and his team from the University of Aberdeen use these cells to mimic the development of the heart muscle in the uterus, in the hope that heart muscle cells grown this way in a vessel can one day help patients who have suffered a heart attack, regenerate damaged tissue results.

Send clones

Dr Myra Britton of the University of Edinburgh and her team are researching clone cells.  The multicolored ribbons pictured above are clone cells on the inside of blood vessels (endothelial cells) in the heart;  these are cells that have copied themselves and then move to areas that are deficient in oxygen, and get to work, creating new blood and lymph vessels.
© Dr Myra Britton, University of Edinburgh

Dr Myra Britton of the University of Edinburgh and her team are researching clone cells. The multicolored ribbons pictured above are clone cells on the inside of blood vessels (endothelial cells) in the heart; these are cells that have copied themselves and then move to areas that are deficient in oxygen, and get to work, creating new blood and lymph vessels.

The Edinburgh team hopes that by finding ways to stimulate these cloned cells after a heart attack, the heart can learn to switch blood vessels to provide damaged areas of the heart with more oxygen. This increase in oxygen and nutrients can save the heart muscle and prevent heart failure.

The development of blood vessels from A … to zebrafish

This figure shows the blood vessels developing a two-day-old zebrafish embryo, with blood and lymphatic vessels labeled with red fluorescent protein.
© Dr. Sarah De Val, Oxford University

This figure shows the blood vessels developing a two-day-old zebrafish embryo, with blood and lymphatic vessels labeled with red fluorescent protein. Marking the veins with green fluorescent protein, the veins glow yellow and the arteries red. By studying zebrafish in this way, Dr. Sarah De Val and her team from Oxford University develop an understanding of exactly how blood vessels develop; their goal is to be able to manipulate the growth of blood vessels in the human heart so that it recovers better after a heart attack or failure.

Healing heart failure

This image shows the part of the heart that is beating - grown in a vessel.  The heart cells, which can be seen dotted with white nuclei, were grown in the laboratory of Professor Sanjay Singh at Cambridge University.
© Professor Sanjay Sinha, Cambridge University

This image shows the part of the heart that is beating – grown in a vessel. The heart cells, which can be seen dotted with white nuclei, were grown in the laboratory of Professor Sanjay Singh at Cambridge University. Professor Sinha and his team use stem cells to grow areas of genuine heart tissue that they hope to apply to damaged areas of the heart so that the heart can recover.

MicroRNA is a shot in the heart

Professor Mauro Jack of King's College London is conducting some stimulating research;  when microRNAs (molecules that exclude genes) are injected into the heart of mice, the proliferation of heart muscle cells is triggered, the heart is stimulated to regenerate, and as a result the thickened heart muscle becomes stronger.
© Professor Moor Jack, KCL

Professor Mauro Jack of King’s College London is conducting some stimulating research; when microRNAs (molecules that exclude genes) are injected into the heart of mice, the proliferation of heart muscle cells is triggered, the heart is stimulated to regenerate, and as a result the thickened heart muscle becomes stronger.

This figure shows heart muscle cells that have been stimulated by the same microRNAs (light green) and cells that proliferate and will strengthen the heart muscle (red dots). Professor Jack and his team hope that the introduction of microRNAs into the heart will stimulate heart cells to regenerate and eliminate the damage seen in people with heart failure.

Study of heart failure branches

Dr. Joaquim Vieira of Oxford University is trying to understand the processes in the embryo that cause the heart to repair itself after an injury.
© Dr. Joaquim Vieira, Oxford University

What looks like the roots of trees that reach for water is actually the structure of blood vessels on the epicardium, the outer surface of the heart.

Dr. Joaquim Vieira of Oxford University is trying to understand the processes in the embryo that cause the heart to repair itself after an injury. Epicardial cells are “involved” in a process called the transition from epithelium to mesenchyme (EMT), and by researching this and understanding the EMT process in the heart, Dr. Vieira believes it re-activates genes and helps heal. damaged hearts may turn into possible therapy.

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